Metabolomics and malaria biology.
نویسندگان
چکیده
Metabolomics has ushered in a novel and multi-disciplinary realm in biological research. It has provided researchers with a platform to combine powerful biochemical, statistical, computational, and bioinformatics techniques to delve into the mysteries of biology and disease. The application of metabolomics to study malaria parasites represents a major advance in our approach towards gaining a more comprehensive perspective on parasite biology and disease etiology. This review attempts to highlight some of the important aspects of the field of metabolomics, and its ongoing and potential future applications to malaria research.
منابع مشابه
Metabolomics in the fight against malaria
Metabolomics uses high-resolution mass spectrometry to provide a chemical fingerprint of thousands of metabolites present in cells, tissues or body fluids. Such metabolic phenotyping has been successfully used to study various biologic processes and disease states. High-resolution metabolomics can shed new light on the intricacies of host-parasite interactions in each stage of the Plasmodium li...
متن کاملEvaluation of the Anticancer Effect of Xanthium Strumarium Root Extract on Human Epithelial Ovarian Cancer Cells Using 1H NMR-Based Metabolomics
Epithelial Ovarian cancer is the leading cause of cancer mortality among women all over the world. As chemotherapeutics has many side effects, researchers have focused on the potential use of medicinal plants as natural antitumor agents. Xanthium strumarium studied in this work as an herbal anticancer agent. This study aimed to evaluate the antitumor effect and metabolic alterations ca...
متن کاملDiscovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach
Natural products continue to play an important role as a source of biologically active substances for the development of new drug. Streptomyces, Gram-positive bacteria which are widely distributed in nature, are one of the most popular sources of natural antibiotics. Recently, by using a bioassay-guided fractionation, an antimalarial compound, Gancidin-W, has been discovered from these bacteria...
متن کاملExtraction of hydrophilic metabolites from Plasmodium falciparum-infected erythrocytes for metabolomic analysis.
Metabolomics is an increasingly common analytical approach for investigating metabolic networks of pathogenic organisms. This may be of particular use in the study of parasitic infections due to the intrinsic metabolic connection between the parasite and its host. In vitro cultures of the malaria parasite Plasmodium falciparum present a valuable platform to elucidate the structure and dynamics ...
متن کاملAn LC/MS Metabolomics Discovery Workfl ow for Malaria-Infected Red Blood Cells Using Mass Profi ler Professional Software and LC-Triple Quadrupole MRM Confi rmation
The utility of a combined un-targeted discovery-based LC/MS and targeted confi rmation LC/MS/MS approach for mining metabolomics data was demonstrated using malaria-infected red blood cells as a model system. Several compounds, including arginine, citrulline, and ornithine, were identifi ed as metabolites whose biosynthesis was altered in erythrocytes infected by the malaria parasite. Authors T...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Molecular and biochemical parasitology
دوره 175 2 شماره
صفحات -
تاریخ انتشار 2011